C-Change has a 22-member Board of Directors that oversees C-Change's operations. Board members have staggered 3-year terms, so that one-third of the members are elected each year.

New Board Members are elected by the entire C-Change membership. A Nominating Committee, the majority of whose members are elected by all C-Change Members, puts together a balanced slate of candidates each year; candidates are selected from a wide representation of the public, private, and nonprofit sectors; the missions of the organizations represented within C-Change; and the representative population groups bearing the greatest cancer burden.

C-Change functions like a virtual "town hall meeting", where distinguished national leaders concerned about the disease come together as a united force at least twice a year to discuss major cancer-related issues. Individual C-Change Members, for whom a particular priority area has special interest or relevance, can then coalesce into smaller issue-driven teams that act together to address the pressing opportunities, barriers, and challenges before them. Individual nongovernmental Members, on their own, may choose to lobby on behalf of federal, state, or local legislation regulation; or administrative rules. However, C-Change as a whole does not engage in lobbying activities.

Leadership

President George H.W. Bush and Barbara Bush, Founding Honorary Chairs
Mike Krzyzewski, Honorary Co-Chair
Senator Dianne Feinstein, Honorary Co-Chair

C-Change Board of Directors provides overall leadership for C-Change's affairs.

President George H.W. Bush and Barbara Bush Founding Honorary Chairs			Robert Croyle, PhD, Federal Liaison National Cancer Institute
	Mike Krzyzewski, Honorary Co-Chair Duke University		Elizabeth Duke, PhD School of Public Policy University of Maryland
	Senator Dianne Feinstein, Honorary Co-Chair US Senate		Lloyd Everson, MD Life Beyond Cancer Foundation
	Governor Bob Wise, Chair Alliance for Excellent Education		Philip Huang, MD, MPH Austin/Travis County Health and Human  Services Department
	Martin Murphy, PhD, DMedSc, Vice Chair CEO Roundtable on Cancer		Tom Kean, MPH C-Change
	Gregory Curt, MD, Treasurer AstraZeneca Pharmaceuticals		Stephen Kindred, MD, MPH State Farm Insurance Companies
	Elizabeth (Betsy) Clark, PhD, ACSW, MPH, Secretary National Association of Social Workers		Allen Lichter, MD American Society of Clinical Oncology
	LaSalle Leffall, Jr., MD, FACS Emeritus Member Howard University Cancer Center		Maureen Lichtveld, MD, MPH Tulane University School of Public Health and Tropical Medicine
	James Marks, MD, MPH, Emeritus Member Robert Wood Johnson Foundation		William Mayer, MD, MPH Bronson Healthcare Group
	John Seffrin, PhD, Emeritus Member American Cancer Society		Lee Newcomer, MD United Health Group
	Jean Becker Office of President George H. W. Bush		Amelie Ramirez, DrPH The University of Texas Health Science Center at San Antonio
	Zora Brown Integris  In Memoriam (1949-2013)		Doug Ulman The LIVESTRONG Foundation

Staff

Tom Kean, MPH, President and CEO
Brian Alexander, Manager, Marketing & Information Systems
Kinga Bartoszek, Vice President, Finance and Operations
Clay Battin, Director of Development and Major Gifts
Kristen Cox Santiago, MS, Manager, Strategic Initiatives
Payal Shah, MPH, Manager, Strategic Initiatives
Brandi Stevenson, CMP, Meetings Manager
Tasha Tilghman-Bryant, MPA, Manager, Strategic Initiatives